|
"In the last year-and-a-half, we have enlisted six cystic fibrosis centers in children's hospitals at universities around the United States - and we'll be happy to do it here in Israel, if you wish - and we have been starting to treat these children. What sense would there have been to try to do animal experiments? It was possible to go to the internal review boards (IRB's) of these institutions, which decide whether you can do "human experimentation", and they all agreed that we could go ahead and do it. The logic was there. It is possible to convince the people in these clinical areas to proceed with a previously untried procedure, if you can show the logic and can convince them of its importance. The CF program has progressed well enough so that we are now expanding to 5 or 6 more CF centers and by the end of the year, we will have collected enough data - no animal experimentation- enough data to have proved the procedure that is literally turning lives around for these children"(120).
-----------------------
References
1) Stiller H. 1973. Animal Experimentation & Animal Experimenters (A Critique of Medicine Based Upon Animal Experimentation) 2) Share,R. 1985. Food & Chem Tox. vol 23. pp139-143 3) Lea,T. 1993. Gene Future. Plenum Press. p177 4) Clarke,LL et al. 1992. Science. vol 257. pp1125-1128 5) Medical Research Modernization Committee website http://www.mrmcmed.org/crit2.html 6) Creighton University School of Medicine website. 7) Tsui,LCet al 1985. Science. vol 230. pp1054-1057 8) NZAVS website http://www.health.org.nz/cf.html 9) Martin,EA [ed]. 1994. Concise Medical Dictionary. 4th ed. Oxford University Press. p164 10) New Scientist. 1989. 21st October. pp54-58 11) Mandaville,A. 2001. BioMedNet News. 27th Sept 12) Santia,G. Geddes,D. 1994. Postgraduate Medical Journal. vol 70. pp247-251. 13) Snouwaert,J N. Brigham,KK et al. 1992. Science. vol 257. pp1083-1088 14) (as ref 12) 15) (as ref 9) 16) (as ref 12) 17) Collins,PS. Wilson,JM. 1992. Nature. vol 358. p708 18) Barinaga,M. 1992. Science. vol 257. p1047. 19) Yankaskas,JR et al. 1985. Lancet. i. pp954-6 20) Science. 1990. vol 249. p455 21) (as ref 10) 22) New Scientist. 1991. 7th December. p34 23) Tsui,LC quoted in (11) 24) Wood,SA et al. 1993. Nature. vol 365. pp87-9 25) Kingman,SM. Kingsman,AJ. 1988. Genetic Engineering. Blackwell Scientific [pub]. pp167-8 26) (as ref 24) 27) (as ref 22) 28) Travis,J. 1992. Science. vol 256. p1394 29) (as ref 12) 30) (as ref 13) 31) Science. 1992. vol 257. pp1046-7 32) (as ref 17) 33) (as ref 13) 34) (as ref 17) 35) (as ref 13) 36) (as ref 18) 37) Koller,B. quoted in ref 18 38) (as ref 18) 39) (as ref 13) 40) (as ref 17) 41) (as ref 18) 42) (as ref 13) 43) Colledge,WH et al. 1992. Lancet. p680 44) Ratcliffe,R et al. 1993. Nature Genetics. vol 4.pp35-41 45) (as ref 13) 46) (as ref 44) 47) (as ref 17) 48) (as ref 18) 49) (as ref 44) 50) Dorin,JR et al. 1992. Nature. vol 359. pp211-5 51) (as ref 17) 52) (as ref 18) 53) New Scientist. 1992. 19th Sept. p6 54) Wilson,JM. Collins,FS. 1992. Nature. vol 359. pp195-6 55) (as ref 44) 56) (as ref 50) 57) (as ref 44) 58) CF News. 1994. Summer. p21 59) Science. vol 2000. pp248-257 60) Nature (1992) 357:31. 61) Peters R. H. et al. (1996). American Journal of Physiology 271: 1074-1083. 62) Greek R from website http://www.satyamag.com/march00/greek.html 63) (as ref 11) 64) Emery,AEH. 1984. Introduction to Recombinant DNA. John Wiley & Sons [pub]. pp4-5 65) Hyde,SC et al. 1993. Nature. vol 362. pp250-5 66) SCRIP. 1993. no 1806. 25th Mar. p25 67) (as ref 65) 68) Alton,EWF et al. 1993. Nature Genetics. vol 5. pp135-142 69) New Scientist. 1995. 25th Nov. pp14-5 70) Collins,FS. 1992. Science. vol 256. pp774-9 71) (as ref 65) 72) SCRIP. 1993. no 1798. p25 73) Yoshimura,K et al. 1992. Nuclei Acids Res. vol 20.pp3233-3240. (cited in ref 62). 74) Stribling,R et al. 1982. Proc nat Acad Sci. vol pp1277-1281. (cited in ref 62) 75) (as ref 65) 76) New Scientist. 1993. 20th Marc.p7 77) SCIP. 1993. no 1792. p19 78) (as ref 68) 79) (as ref 62) 80) (as ref 76) 81) New Scientist. 1993. 2nd Sept. p4 82) (as ref 70) 83) (as ref 81) 84) SCRIP. 1993. no 1867. p20 85) Crystal,R. 1994. Nature Genetics. Sept. p42 86) SCRIP. 1994. no 1958. 16th Sept. p21 87) (as ref 86) 88) (as ref 87) 89) (as ref 69) 90) Lancet. 1995. vol 346. p1617 91) Erickson,R. in ref 54. p15 92) (see ref 69) 93) Crystal,R in ref 54. p15 94) NIH Report. in Science. 1995. vol 270. p1751 95) Varmus,H. in New Scientist. 1995. 16th Dec. p5 continued previous page beginning of this article
96) Orkin,SH. in ref 71. p1617 97) Marshall,E. in Science. 1995. vol 270. p1751 98) (as ref 76) 100) (as ref 87) 101) (as ref 12) 102) (as ref 76) 103) (as ref 12) 104) SCRIP. 1994. no 1958. 16th Sept. p4 105) (as ref 12) 106) (as ref 69) 107) Mayo Clinic. 2002. website 108) SCRIP. 1994. May. pp23-24 109) SCRIP. 1990. no 1521. 8th June. p30 110) (as ref 106) 111) (as ref 107) 112) (as ref 106) 113) (as ref 107) 114) (as ref 106)
|
|