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A brief history of toxicology testing on animals /11
2. The numbers game: how animal-based toxicological risk assessment works The US National Toxicological program /19 Toxicological risk assessment: a brief overview /20 How the NTP animal testing program works /21 The species and numbers of animals used in toxicity tests /21 How animal testing is performed /24 How animal data are extrapolated to humans /27 How animal data are used within the regulatory framework /28
3. For the public good? Debunking the animal testing myth The arguments in favor of animal testing /44 The arguments against /49 The difficulty of inter-species extrapolation /50 False positives/false negatives /57 Different testing methods produce different results /60 The artificiality of laboratory life /64 Humans make mistakes /68 The animal tests have never been validated /69 A criticism of specific tests and methods /74 Humanitarian considerations /78 Time and cost of testing /84
4. Human health at risk Criticism of the risk assessment process /103 Getting away with murder /106 Why animal tests do not protect humans from toxins /109 Particular chemicals as examples /112 The laws and guidelines governing animal testing requirements /122 The business of animal testing: who profits? /131
5. Toxicological testing without using animals The alternatives concept /153 Examples of non-animal toxicological testing methods /152 The 'alternatives' scam: refinement and reduction vs. full replacement /168 The validation issue: a barrier to a full and immediate ban on animal testing /179 Some success stories /186
6. Reclaiming our health and our humanity: strategies for change The need for a new paradigm /209 Chemical bans /214 The path to revolution: forms of public protest /217 The activist struggle in the face of economic globalization /219 Environmentalists and animal advocates: a necessary union /220 Legislation /222 The False Claims Act: a legal challenge to the the US government /223 The future of toxicity testing without animals /225
To help avoid this unnecessary and worthless orgy of animal testing that will result in millions of animals dying painful deaths, your letters are needed to:
Vice President Al Gore Old Executive Office Building Washington DC 20601
Carol M Browner, EPA 401 M Street SW Washington DC 200460 Fax 202-260-0279
Fred Krupp, Executive director Environmental Defense Fund 257 Park Avenue South New York NY 10010 Fax 212-205-2375
Frederick L. lWebber, President Chemical Manufacturers Association 1300 Wilson Boulevard Arlington VA Fax 703-741-6000
Dr Gerald Pflug, President Soap and Toiletry Association 475 Park Avenue South New York NY 10018 Fax 212-213-1685
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